Kits
BAFF, ELISA
- 貨號 Cat. No.
- K 9410
- 規格 Size
- 96 Tests
- 品牌 Brand
- IDS
Description
| Article number: | K 9410 |
| Method: | ELISA |
| Tests: | 96 Tests |
| Matrix: | Serum, Cell Culture Supernatant |
| Volume: | 50 µl |
| Incubation time: | 2h; 1.5h; 2h; 10-20min |
| Standards: | 0-128 ng/ml |
| BAFF (B cell activating factor belonging to the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFFR, TACI and BCMA) predominantly expressed on B cells, although activated T cells also express BAFFR. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Beside its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form by proteolytic cleavage, leads to autoimmune disorders in mice. In the human, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as rheumatoid arthritis (RA), Sjögren‘s syndrome (SS) and systemic lupus erythematosus (SLE). BAFF levels are also elevated in patients with multiple myeloma and B-cell chronic lymphoid leukemia (B-CCL). Our BAFF ELISA determines soluble human BAFF in serum and in cell culture supernatant. |