Kits
BackHydroxy Pyridinium Crosslinks (PYD/DPD) HPLC
Kits
Description
The hydroxypyridinium compounds pyridinoline (PYD) and deoxypyridinoline (DPD)
are specific constituents of mature skeletal collagens. They are released into the circulation
and excreted in the urine. Their measurement in urine is a sensitive index of
the extent of ongoing bone resorption. The quantification of collagen crosslinks in
urine is achieved by chromatographic techniques.
Clinical applications of hydroxypyridinium markers include numerous metabolic
bone disorders such as osteoporosis, primary hyperparathyroidism, Paget´s disease
of bone, and metastatic bone disease. Urinary pyridinium crosslinks of collagen also
show great promise as markers of therapeutic efficacy in bone disorders associated
with accelerated bone resorption.
are specific constituents of mature skeletal collagens. They are released into the circulation
and excreted in the urine. Their measurement in urine is a sensitive index of
the extent of ongoing bone resorption. The quantification of collagen crosslinks in
urine is achieved by chromatographic techniques.
Clinical applications of hydroxypyridinium markers include numerous metabolic
bone disorders such as osteoporosis, primary hyperparathyroidism, Paget´s disease
of bone, and metastatic bone disease. Urinary pyridinium crosslinks of collagen also
show great promise as markers of therapeutic efficacy in bone disorders associated
with accelerated bone resorption.