BACE2, Mouse Antibody

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Beta-secretase 2; Aspartic-like protease; Aspartyl protease 1; Asp1; Beta-site amyloid precursor protein cleaving enzyme 2; Down syndrome aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; theta-secretase

 

Antibody_Isotype
(Antibody only) : IgG1kappa

 

Application_Details :

The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 690 and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) : 1/ 9

 

Datasheet_Link :

 

Description (Long Description) : 

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG format, for improved compatibility with existing reagents, assays and techniques. The antibody binds specifically to BACE2, an enzyme responsible for the proteolytic cleavage of amyloid precursor protein (APP). The protein is cleaved between residues 69and 691, leading to the formation of beta-cleaved soluble APP and a C-terminal membrane bound fragment (CTFβ). The latter is then cleaved by gamma-secretase to generate amyloid beta peptide. BACE is the rate-limiting enzyme in the pathway, and is a potential target in the treatment of Alzheimer's Disease (AD),a neurodegenerative disorder characterised by amyloid beta plaques within the brain. The BACE2 protein is encoded in chromosome 21, in a region critical for the development of Down's Syndrome, and may play a role in the amyloid beta deposition in the disease.

 

Expiry_Date : 

12 months after purchase if unopened.

 

Format (Form) : 

Liquid, PBS with 0.02% Proclin 300.

 

Immunogen (Antigen) :Human BACE2 244–333.

 

Kit_Components :

 

MSDS (File name) :