BACE Polyclonal Antibody
- 貨號 Cat. No.
- 6101-100
- 規格 Size
- 100 ug
Description
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 490 of human BACE./p
pbSPECIES REACTIVITY:/b human, mouse/p
pbBACKGROUND:/b Accumulation of the amyloid-? (A?) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. A? peptide is generated by proteolytic cleavage of the ??amyloid protein precursor (APP) at ?- and ?-sites by two proteases. APP is first cleaved by ?-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for ?-secretase to generate the 4 kDa amyloid-? peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought ?-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP./p
pbFORMULATION:/b 100 ug (0.5 mg/ml) purified rabbit anti-BACE polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSTORAGE CONDITIONS:/b Store at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbAPPLICATION AND USAGE:/b The antibody detects ~70 kDa BACE by Western blot analysis (1-4 ug/ml). However, the optimal conditions should be determined individually. Human brain tissue lysate can be used as a positive control./p
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide surrounding amino acid 490 of human BACE./p
pbSPECIES REACTIVITY:/b human, mouse/p
pbBACKGROUND:/b Accumulation of the amyloid-? (A?) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. A? peptide is generated by proteolytic cleavage of the ??amyloid protein precursor (APP) at ?- and ?-sites by two proteases. APP is first cleaved by ?-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for ?-secretase to generate the 4 kDa amyloid-? peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought ?-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP./p
pbFORMULATION:/b 100 ug (0.5 mg/ml) purified rabbit anti-BACE polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal./p
pbSTORAGE CONDITIONS:/b Store at -20oC. For long-term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbAPPLICATION AND USAGE:/b The antibody detects ~70 kDa BACE by Western blot analysis (1-4 ug/ml). However, the optimal conditions should be determined individually. Human brain tissue lysate can be used as a positive control./p
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