B7-H4 Antibody

Catalog Number

250473

Unit

0.1 mg

 

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

Immune costimulatory protein B7-H4 (B7-H4) is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell response. By arresting cell cycle, B7-H4 inhibits growth, cytokine secretion and cytotoxicity development. When expressed on the cell surface of tumor macrophages, B7-H4 plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7-H4 is also involved in promoting epithelial cell transformation. B7-H4 can be a predictive marker for renal cell carcinoma.

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Alternate Names

V-set domain-containing T-cell activation inhibitor 1; Immune costimulatory protein B7-H4; B7h.5; T-cell costimulatory molecule B7x; Protein B7S1; VTCN1; B7H4

Accession No.

Q7Z7D3

 

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of human B7-H4.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500

IHC: 1:200-500

Reacts with  :H | M | R

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.