B-Cell Activating Factor (BAFF) ELISA

pB-Cell Activating Factor br /
(BAFF) ELISAbr /
nbsp;/p
pimg alt=For Research Use Only src=http://www.alpco.com/img/ruo.gif align=absMiddle / For Research Use Only/p
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div class=prod_specbFormat:/b/div
div class=prod_spec_infoELISA / EIA/div
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div class=prod_specSample Type:/div
div class=prod_spec_infoserum, cell culture/div
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div class=prod_specbSample Size:/b/div
div class=prod_spec_info50 micro;l/div
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div class=prod_specbSize:/b/div
div class=prod_spec_info96 wells/div
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div class=prod_specbRange:/b/div
div class=prod_spec_info2 - 128 ng/ml/div
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div class=prod_specbSensitivity:/b/div
div class=prod_spec_info0.95 ng/ml/div
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div class=prod_specbIncubation Time:/b/div
div class=prod_spec_info5 hour(s) 50 min(s)/div
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pbSummary:/b/p
BAFF (B cell activating factor belonging to the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFFR, TACI and BCMA) predominantly expressed on B cells, although activated T cells also express BAFFR. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Beside its major role in B cell biology, BAFF co-stimulates activated T cells. br /
br /
Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form by proteolytic cleavage, leads to autoimmune disorders in mice. In the human, elevated levels of soluble BAFF have been detected in the serum of individuals with various autoimmune diseases, such as rheumatoid arthritis (RA), Sjouml;gren syndrome (SS) and systemic lupus erythematosus (SLE). BAFF levels are also elevated in individuals with multiple myeloma and B-cell chronic lymphoid leukemia (B-CCL)./div
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