b-Catenin Polyclonal Ab
- 貨號 Cat. No.
- 3380-100
- 規格 Size
- 100 ug
Description
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide corresponding to residues around 40 of human ?-Catenin./p
pbFORMULATION:/b 100 ug (0.5 mg/ml) immunoaffinity purified rabbit polyclonal anti-?-Catenin antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal/p
pbSPECIES REACTIVITY:/b human, mouse, rat/p
pbSTORAGE CONDITIONS:/b Store at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND:/b Catenin is one of the key downstream effectors in the Wnt signaling pathway. It has been implicated to play an important role in early embryonic development and tumorigenesis. ?-catenin can be destabilized by GSK-3? or other kinases by phosphorylating it at serines 33, 37, 45 and threonine 41. Mutations of these phosphorylation sites in ?-catenin have been found in many tumor cell lines./p
pbSPECIFICITY:/b The antibody recognizes 90 kDa ?-Catenin of human, mouse, and rat origin. It does not recognize ?-catenin and ?-catenin../p
pbAPPLICATION:/b The antibody can be used for Western blotting (0.5-4 ug/ml). Based on researchers feedback, it also works in immunohistochemistry (20 ug/ml). However, the optimal concentrations should be determined individually./p
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pbHOST:/b Rabbit/p
pbIMMUNOGEN:/b Synthetic peptide corresponding to residues around 40 of human ?-Catenin./p
pbFORMULATION:/b 100 ug (0.5 mg/ml) immunoaffinity purified rabbit polyclonal anti-?-Catenin antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% thimerosal/p
pbSPECIES REACTIVITY:/b human, mouse, rat/p
pbSTORAGE CONDITIONS:/b Store at -20oC. For long term storage, aliquot and freeze at -70oC. Avoid repeated freeze/defrost cycles./p
pbBACKGROUND:/b Catenin is one of the key downstream effectors in the Wnt signaling pathway. It has been implicated to play an important role in early embryonic development and tumorigenesis. ?-catenin can be destabilized by GSK-3? or other kinases by phosphorylating it at serines 33, 37, 45 and threonine 41. Mutations of these phosphorylation sites in ?-catenin have been found in many tumor cell lines./p
pbSPECIFICITY:/b The antibody recognizes 90 kDa ?-Catenin of human, mouse, and rat origin. It does not recognize ?-catenin and ?-catenin../p
pbAPPLICATION:/b The antibody can be used for Western blotting (0.5-4 ug/ml). Based on researchers feedback, it also works in immunohistochemistry (20 ug/ml). However, the optimal concentrations should be determined individually./p