AZD3463
Chemical Compounds
- 貨號 Cat. No.
- M2109
- 規格 Size
- 10mg,50mg
- 品牌 Brand
- No Brand
Description
AZD3463 is a novel inhibitor of ALK which overcomes multiple mechanisms of acquired resistance to crizotinib. AZD3463 inhibits ALK with a Ki value of 0.75 nM. AZD3463 dose-dependently inhibits pALK in tumor xenografts in vivo, resulting in stasis (H3122) or regression (DEL, H2228) in tumor volume. AZD3463 obtains equivalent potency to mutantL1196M and wild-type ALK in vivo.
