Aurora A Antibody

Aurora A (Serine/threonine-protein kinase 6) contributes to the regulation of cell cycle progression and is required for normal mitosis. Aurora A associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. It phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Aurora A plays a role in microtubule remodeling during neurite extension, and is important for microtubule formation and/or stabilization.