AURKB (13E) Antibody

Aurora B is involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Aurora B is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Aurora B phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis, and is required for kinetochore localization of BUB1 and SGOL1.