Asp371 Tyrosinase [369-377] Peptide

The peptide is a tumor antigenic peptide that activates antigen-presenting cells (APC) and is displayed on melanoma tumor cells. The sequence corresponds to the mutated N371D glycosylation site analog within residues 369-377 of human tyrosinase (TYR). The TYR enzyme is an oxidase that is involved in the formation of pigments such as melanins and other polyphenolic compounds by tyrosine conversion. TYR defects are the cause of oculocutaneous albinism, characterized by the absence of pigment in hair, skin and eyes.