Asenapine

貨號 Cat. No.: S1283
規格 Size: 5~200mg
品牌 Brand: Selleckchem

Description

Asenapine

Catalog No.S1283

Asenapine inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.

Size

Price

Stock

Quantity

10mM/1mLIn DMSO	USD 88	In stock	0 1 2 3 4 5 6 7 8 9 10
10mg	USD 63	In stock	0 1 2 3 4 5 6 7 8 9 10
50mg	USD 214	In stock	0 1 2 3 4 5 6 7 8 9 10
100mg	USD 340	In stock	0 1 2 3 4 5 6 7 8 9 10

Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw

Biological Activity

Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder.

Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors. Asenapine behaves as an antagonist at all receptors. [1]

Clinical Trial Information( data from http://clinicaltrials.gov)

NCT Number	Recruitment	Conditions	Sponsor /Collaborators	Phases
NCT02072954	Active, not recruiting	Schizophrenia	Amneal Pharmaceuticals, LLC\|Accutest Research Laboratories (I) Pvt. Ltd.	Phase 2\|Phase 3
NCT01807741	Recruiting	Bipolar Depression	University of Cincinnati\|University of Louisville\|Merck Sharp & Dohme Corp.	Phase 2
NCT01948024	Completed	Schizophrenia\|Bipolar Disorder	bioRASI, LLC\|Sun Pharmaceutical Industries Limited	Phase 1
NCT01495741	Active, not recruiting	Bipolar Disorder\|Schizophrenia	Merck Sharp & Dohme Corp.

Chemical Information

Download Asenapine SDF

Molecular Weight (MW)	401.84
Formula	C17H16ClNO.C4H4O4
CAS No.	85650-56-2

Storage	3 years -20â„ƒPowder
Storage	6 months-80â„ƒin DMSO
Syonnyms	Saphris

Solubility (25°C) *	In vitro	DMSO	80 mg/mL (199 mM)
		Water	<1 mg/mL (<1 mM)
		Ethanol	<1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.