AQP2 Antibody

Aquaporin-2 (AQP-2) forms a water specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. It is expressed in the renal collecting tubules. Defects in AQP2 are a cause of autosomal recessive nephrogenic diabetes insipidus (ANDI), also known as diabetes insipidus nephrogenic type 2. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria). Belongs to the MIP/aquaporin (TC1.A.8) family.