AQP1 Antibody

Aquaporin-1 (AQP1) forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. AQP1 is responsible for the Colton blood group system. Approximately 92% of Caucasians are Co(A+B-) (Ala-46), approximately 8% are Co(A+B+), and only 0.2% are Co(A-B+) (Val-46). Co(A-B-), which is very rare, is due to a complete absence of AQP1. AQP1 is pharmacologically inhibited by submillimolar concentrations of mercury.