Apramycin Antibody

Apramycin is shown to be a potent inhibitor of protein synthesis in bacteria both in vivo and in vitro. Apramycin inhibits the translocation step of protein synthesis both in vivo, in protoplasts of Bacillus megaterium, and in vitro, in cell-free systems from E. coli. It is proposed that this is the primary inhibitory effect of the drug