APP Antibody

Catalog Number

250545

Unit

0.1 mg

 

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

The Amyloid Protein Precursor (APP) is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, whereas others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). In addition, APP is associated with neurological disorders related to type II diabetes and Down's syndrome.

Product Citations

Recommended Products

Alternate Names

Amyloid beta A4 protein; Alzheimer disease amyloid protein; ABPP; APPI; APP PreA4; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; A4; APP; AD1

Accession No.

P05067

 

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing the human APP695 sequence.

Application Notes

This antibody reacts with human, mouse and rat APP695 but not with APP770.

E: 1:500-1:1,000

WB: 1:100-1:500

IHC: 1:200-1:500

IP:Use at an assay dependent concentration

 Reacts with  :H | M | R

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.