Apolipoprotein A-1 Antibody

Apolipoprotein A-1 (APOA1) participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, APOA1 activates spermatozoa motility. Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2), also known as familial hypoalphalipoproteinemia (FHA). Inheritance is autosomal dominant.