ApoA1 (5F4F) Antibody

APOA1 (Apolipoprotein A-1) participates in the reverse transport of cholesterol from tissues to the liver. It is promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, APOA1 activates spermatozoa motility. Defects in APOA1 are a cause of high density lipoprotein deficiency type 2 (HDLD2), also known as familial hypoalphalipoproteinemia (FHA). Inheritance is autosomal dominant.