Apo-E Antibody

Catalog Number

250544

Unit

0.1 mg

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

Apolipoprotein E (Apo-E) is a protein component of plasma lipoprotein that mediates the binding, internalization and catabolism of lipoprotein particles. Apo-E can serve as a ligand for the LDL (Apo-B/E) receptor and for the specific Apo-E receptor (chylomicron remnant) of hepatic tissues. Apo-E is present in all lipoprotein fractions in plasma and constitutes 10-20% of very low density lipoproteins (VLDL)  and 1-2% of high density lipoproteins (HDL) . Apo-E is produced in most organs. Defects in Apo-E are a cause of hyperlipoproteinemia type III (lipid deposits in palms, tendons and elbows), sea-blue histiocyte disease (splenomegaly, thrombocytopenia), and lipoprotein glomerulopathy.

Product Citations

Recommended Products

Alternate Names

Apolipoprotein E; Apo-E; APOE

Accession No.

P02649

 

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of mouse Apo-E.

Application Notes

E: 1:500-1:1,000

WB: 1:100-1:500

IHC: 1:100-1:500

Reacts with  : M | R

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.