Apaf-1 (N-term) Antibody

Catalog Number

250543

Unit

0.1 mg

 

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Data and Images

Description

Apoptosis protease activating factor-1 (Apaf-1) mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3) by forming oligomer upon binding with cytochrome c and dATP. Oligomeric Apaf-1 binds to pro-caspase 9 through their N-terminal CARD domains releasing mature caspase-9.

Product Citations

Recommended Products

Alternate Names

Apoptotic protease-activating factor 1; Apaf-1; APAF1

Accession No.

O14727

 

Clonality

Antigen

KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Apaf-1.

Application Notes

E: 1:500-1:1,000

WB: 1:200-1:500

IHC: 1:200-1:500

IP:Use at an assay dependent concentration

Reacts with  :H | M | R

Storage

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.