AP24534
Chemical Compounds
- 貨號 Cat. No.
- M1648
- 規格 Size
- 10mg,50mg,100mg
- 品牌 Brand
- No Brand
Description
Ponatinib (AP24534) is a novel potent BCR-ABL or BCR-ABLT3151 with an IC50 values of 0.37 and 2.0 nM, respectively. Ponatinib (AP24534) also inhibits other ABL kinase domain mutants at nanomolar potencies. AP24534 exhibits inhibitory activity against PDGFRα, c-Src and c-Kit (IC50 values are 1.1, 5.4 and 12.5 nM respectively) potently inhibits FGFR and VEGFR family kinases.
