Anti-TRPV4-ATTO-550
- 貨號 Cat. No.
- ACC-034-AO
- 規格 Size
- 50 μl
Description
Anti-TRPV4-ATTO-550
| Product#: | ACC-034-AO |
| Sizes: |
| 50 µl |
| Host: |
Rabbit. Host: |
| Epitope: |
| Peptide CDGHQQGYAPKWRAEDAPL, corresponding to amino acid residues 853-871 of rat TRPV4 (Accession Q9ERZ8). |
| Putative epitope location: |
Intracellular, C-Terminus. |
 |
| Homology: | ||
Mouse - 17/19 amino acid residues identical; human 16/19 amino acid residues identical.
|
| Reactivity Confirmed: |
Rat. Standard Quality Control of each lot:
|
Applications:
| Immunohistochemistry: |
| Expression of TRPV4 in rat DRG |
 |
| Immunohistochemical staining of rat dorsal root ganglia (DRG) frozen sections with Anti-TRPV4-ATTO-550 antibody (#ACC-034-AO), (1:20). TRPV4 is present in DRG neurons (red). Note that staining is stronger in small cells (arrows). Hoechst 33342 is used as the counterstain. |
TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously
expressed in excitable and non-excitable cells1. According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence
homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP)1-4. The TRPV subfamily consists of six members, TRPV1-65. TRPV4 (also named OTRPC4) is activated under hypotonic conditions and serves as an osmoreceptor. TRPV4 is expressed in brain, liver, kidney, heart, testis and salivary gland6.
Alomone Labs offers a highly specific antibody directed against an intracellular epitope of TRPV4. Anti-TRPV4 antibody (#ACC-034) can be used in Western blot, immunocytochemical, and immunohistochemical applications and recognizes TRPV4 from rat samples.
Alomone Labs is pleased to offer a new version of this antibody, Anti-TRPV4-ATTO-550 antibody (#ACC-034-AO), that is directly labeled with an ATTO-550 fluorescent dye. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-550 fluorescent label is related to the well known dye Rhodamine 6G and can be used with filters typically used to detect Rhodamine. Anti-TRPV4-ATTO-550 antibody has been tested in immunohistochemical applications and is specially suited for experiments requiring simultaneous labeling of different markers.