- 貨號 Cat. No.
- ACC-020
- 規格 Size
- 50 μl 0.2ml
Description
Anti-TRPC5
Epitope: |
Peptide (C)HKWGDGQEEQVTTRL corresponding to amino acid residues 959-973 of human TRPC5 (Accession number Q9UL62). |
Putative epitope location: |
Intracellular, C-terminus. |
Homology: |
Rat, Mouse, Rabbit - identical. |
Reactivity Confirmed: |
Rat. |
Applications:
 |
Western blotting of rat brain membranes:
1. Anti-TRPC5 antibody (#ACC-020) (1:200).
2. Anti-TRPC5 antibody, preincubated with the control peptide antigen. |
1. Moran, M.M. et al. (2004) Current Opin. Neurobiol. 14, 362. |
2. Clapham, D.E. et al. (2003) Pharmacol. Rev. 55, 591. |
3. Clapham, D.E. (2003) Nature 426, 517. |
4. Padinjat, R. and Andrews, S. (2004) J. Cell. Sci. 117, 5707. |
5. Huang, C.L. (2004) J. Am. Soc. Nephrol. 15, 1690. |
6. Liu, X. et al. (2003) J. Biol.Chem. 278, 11337. |
The Transient Receptor Potential (TRP) superfamily is one of the largest ion channel families and consists of diverse groups of proteins. In mammals
about 28 genes encode the TRP ion channel subunits. The mammalian TRP superfamily comprises six subfamilies known as the TRPC (canonical), TRPV
(vanilloid), TRPM (melastatin), TRPML (mucolipins), TRPP (polycystin) and the TRPA (ANKTM1) ion channels.1-4
The TRPC subfamily consists of seven proteins named TRPC1 to 7 which can be further divided into four subgroups based on their sequence homology and
functional similarities: 1.) the TRPC1 2.) TRPC4 and TRPC5 3.) TRPC3, TRPC6, TRPC7 4.) TRPC2.2,5 They are highly expressed in the central nervous system
and to a lesser extent in peripheral tissues.
TRPC5 channels are assumed to form components of store operated channels in some cell types such as salivary gland cells, endothelial cells and vascular
smooth muscle cells, and can be activated either by calcium store depletion or by GPCR stimulation pathways.6
詢價 / 洽詢此產品
