Anti-TG ELISA

Thyroglobulin (Tg) is a protein produced by and used
entirely within the thyroid gland. Thyroglobulin is used by
the thyroid gland to produce the thyroid hormones
thyroxine (T4) and triiodothyronine (T3).
Thyroglobulin synthesis is stimulated at the transcriptional
level by thyroid-stimulating hormone (TSH) Thyroglobulin
(Tg) is a well-known target for autoantibodies occurring in
thyroid autoimmunity (Graves' disease and Hashimoto's
thyroiditis). Anti-Tg antibodies mostly belong to the IgG
class. Low to moderate levels of anti-Tg antibodies can be
found in sera of other autoimmune patients (eg systemic
lupus erythematosus or Sjogren syndrome). In some cases
anti-Tg positive sera may show negativity for other type of
anti-thyroid antibodies - anti-TPO.
Therefore, combined determination of both types of antithyroid
antibodies (anti-TPO + anti-Tg) provides most
sensitive laboratory diagnostic tool for thyroid
autoimmunity. Separately from autoimmunity, anti-Tg
antibodies may develop in patients suffering from thyroid
cancer. High level of anti-Tg in such patients may interfere
with correct determination of serum thyroglobulin, which
serves as tumour marker for therapy control in this group of
patients.