Anti-Somatostatin Receptor Type I

Anti-Somatostatin Receptor Type I

Product#:

ASR-001

Sizes:

50 ml

0.2 ml

Somatostatin is a small cyclic peptide that is widely expressed throughout the central nervous system and peripheral tissues.¹ In peripheral tissues, somatostatin exerts inhibitory effects on secretion processes, whereas in the brain it acts as a neurotransmitter in both stimulatory and inhibitory manner.^{1, 2} Somatostatin mediates its action via six high affinity G-protein coupled receptors (SSTR1, SSTR2a, SSTR2b, SSTR3, SSTR4 and SSTR5) which are encoded by five genes.^1,2 Expression of the different receptors is developmentally regulated in a time and tissue-specific manner.² Somatostatin receptors have been found on a variety of neuroendocrine tumors, such as paragangliomas, carcinoids and breast tumors.³ Synthetic peptide derivatives of somatostatin have been successfully used in the treatment of neuroendocrine malignancies and in in vivo imaging of tumors that are positive to somatostatin receptors.⁴

Host:

Rabbit.

Epitope:

Peptide CSRGPGSGAADGMEE, corresponding to residues 26-40 of rat somatostatin receptor type 1 (Accession# P28646).

Putative epitope location:

Extracellular, N-Terminus.

Homology:

Mouse ?identical, human ?13/15 residues identical.

Reactivity Confirmed:

Rat.

Applications:

Western Blotting:

Western blotting of rat brain lysate: 1. Anti-SSTR1 antibody, 1:200. 2. Anti-SSTR1 antibody, preincubated with the control peptide antigen.

Control antigen included in price

References:

1.	Hofland, LJ. and Lamberts, S.W.J. (2001) Annals of Oncology 12, S31.
2.	Fombonne, J. et al. (2003) Rep. Biol. Endocrinol. 1, 19.
3.	Slooter, G.D. et al. (2001) Br. J. Surg. 88, 31.
4.	Schulz, S. et al. (2002) Gynecologic Oncology 84, 235.