Anti-Somatostatin Receptor Type 5 (extracellular)
- 貨號 Cat. No.
- ASR-005
- 規格 Size
- 50 μl 0.2ml
Description
Anti-Somatostatin Receptor Type 5 (extracellular)
| Product#: | ASR-005 |
| Sizes: |
| 50 µl |
| 0.2 ml |
| Host: | ||
Rabbit.
|
| Epitope: |
Peptide CEPLSLASTPSWNAS corresponding to amino acid residues 2-15 of rat somatostatin receptor type 5 (accession P30938). |
 |
| Putative epitope location: |
Extracellular, N-terminus. |
| Homology: |
Mouse-identical, Human-12/14 amino acid residues identical. |
| Reactivity Confirmed: |
Rat. |
Applications:
| Western Blotting: |
 | Western blot analysis of SSTR5 in rat brain lysates: |
| Immunohistochemistry: |
Expression of SSTR5 in mouse cerebellum |
 |
Immunohistochemical staining of Somatostatin receptor 5 (SST5R) in mouse cerebellum using Anti-Somatostatin Receptor Type 5 (extracellular) antibody (#ASR-005). A, SST5R (red) appears in Purkinje cells (horizontal arrows) and in molecular layer interneurons (vertical arrows). B, Parvalbumin (green) appears in the Purkinje cells and their processes. C, merge of SST5R and parvalbumin demonstrates co-localization in Purkinje cells (horizontal arrows) but not in the molecular layer (vertical cells). The blue counterstain is DAPI. |
Somatostatin (SST) is a small cyclic peptide that was first identified as a powerful inhibitor of the secretion of various hormones including growth hormone (GH), thyroid-stimulating hormone (TSH) and prolactin from the pituitary, as well as practically every major hormone from the intestinal tract. SST consists of two major bioactive forms, SST-14 and the N-terminus extended peptide SST-28, that can be produced by a wide variety of neuroendocrine, inflammatory and immune cells. In target cells, SST induces a variety of physiological functions that include neuromodulation, cell secretion, cell proliferation and smooth muscle contractility.
SST acts on its multiple cell targets via a family of six receptors that originate from five genes: SSTR1, SSTR2a, SSTR2b, SSTRR3, SSTR4, SSTR5. The SSTRs are members of the G-protein coupled receptor superfamily and they modulate cell response via multiple second messenger systems such as inhibition of adenylate cyclase, modulation of conductance of ion channels and protein dephosphorylation.
In contrast to SSTR1-4 that bind SST-14 and SST-28 with similar affinity, SSTR5 has a much greater affinity to SST-28 over SST-14.
SSTRs are widely expressed in both brain and peripheral tissues but with receptor subtype variations between the different cell types.
Strong SSTR expression has been detected in a variety of human tumors including pancreatic, breast, lung and prostate cancers. In fact, SST has been shown to inhibit the growth of various normal and tumor cells. On this basis, several long lasting SST analogs have been developed and are being tested for use in several pathologies such as various cancers, acromegaly, immunoproliferative disorders, diabetic retinopathy, epilepsy and pain.
SSTR5 is expressed in a variety of tissues and cells, including pancreas, colonic mucosa, small intestine, heart, and vascular smooth muscle cells.
SSTR5 has been shown to mediate growth inhibition and cell proliferation, and to play an important role in cancer growth regulation as one of the most potent inhibitory receptors.
We are pleased to release the anti-SSTR5 (extracellular) antibody, thus completing the series of Anti-Somatostatin Receptor antibodies.