Anti-Parkin
- 貨號 Cat. No.
- A-152
- 規格 Size
- 100 μg
- 品牌 Brand
- Boston Biochem
Description
Anti-Parkin
rabbit polyclonal
Product Information
100 μg
100 μg of antibody in PBS with 1 mg/ml BSA + 0.05% NaN3. Epitope purified antibody.
Synthetic Peptide: C I298 K E L H H F R I L G E E Q Y N313 of human parkin. This sequence is conserved in mouse and rat.
Antibody detects recombinant human Parkin (52 kDa).
Use & Storage
Store vial at -80°C. Avoid repeated freeze-thaw cycles.
Recommended dilution for Western blot is between 1:200 and 1:600. Investigator should empirically determine optimal working dilutions.
Catalog #: A-152
Anti-Parkin
Product Source:
rabbit polyclonal
Parkin, a 52 kDa protein, has a role in the ubiquitin/proteasome pathway for protein degradation. The amino terminus bears sequence homology to ubiquitin and it functions as a RING-type E3 ubiquitin ligase that coordinates the transfer of ubiquitin to substrate proteins, thus targeting them for degradation by the proteasome. Studies show that parkin ubiquitinates the alpha-synuclein interacting protein, synphilin-1. Recent analysis of parkin mutations in Autosomal Recessive Juvenile Parkinsonism (AR-JP) patients reveals that parkin becomes functionally inactive as an E3 enzyme. This loss of function mutation within parkin results in a failure of UPP-mediated proteolysis of synphilin-1 and the accumulation of proteins within the cell resulting in neuronal cell death.
Product Information
Quantity:
100 μg
Stock:
100 μg of antibody in PBS with 1 mg/ml BSA + 0.05% NaN3. Epitope purified antibody.
Immunogen:
Synthetic Peptide: C I298 K E L H H F R I L G E E Q Y N313 of human parkin. This sequence is conserved in mouse and rat.
Reactivity:
Antibody detects recombinant human Parkin (52 kDa).
Use & Storage
Storage:
Store vial at -80°C. Avoid repeated freeze-thaw cycles.
Specificity:
Recommended dilution for Western blot is between 1:200 and 1:600. Investigator should empirically determine optimal working dilutions.