Anti-P2Y14 (extracellular)
- 貨號 Cat. No.
- APR-018
- 規格 Size
- 50 μl 0.2ml
Description
Anti-P2Y14 (extracellular)
| Product#: | APR-018 |
| Sizes: |
| 50 ml |
| 0.2 ml |
| Host: |
| Rabbit. |
| Epitope: |
Peptide CIELKSELGRKWHKASN corresponding to residues 172-188 of human P2Y14 (Accession# Q15391). |
 |
| Putative epitope location: |
2nd extracellular loop. |
| Homology: |
Rat, mouse ?15/17 residues identical. |
| Reactivity Confirmed: |
Rat, human. |
Applications:
| Western Blotting: |
Rat brain and lung lysates, and rat heart membrane (1:200). |
 | Western blotting of rat heart membranes (lanes 1,4), rat brain (lanes 2,5) and rat lung lysates (lanes 3,6):
|
| Flow Cytometry: |
| Indirect Flow Cytometry: 5-10ç—¢ antibody / 1x106cells. |
| References: |
| 1. Chambers, J.K. et al. (2000) J. Biol. Chem. 275, 10767. |
| 2. Abbracchio, M.P. et al. (2003) Trends Pharmacol. Sci. 24, 52. |
| 3. Skelton, L. et al. (2003) J. Immunol. 171, 1941. |
P2Y14 belongs to the P2Y receptor family that is part of the G-protein coupled receptor superfamily. To date eight functional mammalian P2Y receptors have been identified: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14.
The P2Y receptor family mediates the effects of extracellular nucleotides such as ATP, ADP, UTP and in the case of P2Y14 UDP-glucose. UDP-glucose as the other nucleotides can be released to the extracellular milieu as the result of cell damage or by regulated non-lytic mechanisms.
P2Y14 is expressed in several tissues including brain, lung and several cells of hematopoietic origin such as T lymphocytes and dendritic cells.
The exact function of this receptor in the different tissues has not been clearly established but an involvement in chemotaxis, maturation of immature dendritic cells and neuroimmune regulation has been suggested.
We have now developed a highly specific Anti-P2Y14 antibody directed against a conserved epitope in the second extracellular loop of the human P2Y14 receptor. The antibody will also recognize human and mouse samples.