Anti-P2Y13
- 貨號 Cat. No.
- APR-017
- 規格 Size
- 50 μl 0.2ml
Description
Anti-P2Y13
| Product#: | APR-017 |
| Sizes: |
| 50 ml |
| 0.2 ml |
| Epitope: |
Peptide DRFLKIIRPLRNIFLK(C) corresponding to residues 119-134 of human P2Y13 (Accession Q9BPV8). |
| Putative epitope location: |
2nd Intracellular loop. |
 |
| Homology: |
Mouse-11/16 residues identical, rat-10/16. |
| Reactivity Confirmed: |
| Rat. |
Applications:
| Western Blotting: |
 | Western blotting of rat brain membranes : 1. Anti-P2Y13 antibody, 1:200 2. Anti-P2Y13 antibody, preincubated with the control peptide antigen |
| Immunohistochemistry: |
| Immunohistochemical Staining of P2Y13 in Rat Testis |
 |
| Paraffin embedded section of rat epidydimus shows strong and high specific staining of the epithelial cells. After antigen retrieval the slide was incubated with Anti-P2Y13 antibody (#APR-017) (1:50) overnight at 4oC. Universal Immuno-alkaline-phosphatase kit followed by New Fuchsin Substrate was used for color reaction (red). Counterstaining is Hematoxilin. |
| References: |
| 1. Communi, D. et al. (2001) J. Biol. Chem. 276, 41479. |
| 2. Zhang, F.L. et al. (2002) J. Pharmacol. Exp. Ther. 301, 705 |
| 3. IUPHAR/GPCR/ReceptorFamilies |
| 4. Wang, L. et al. (2005) Circ. Res. 96, 189. |
| 5. Wirkner, K. et al. (2004) Br. J. Pharmacol. 141, 141. |
The P2Y family belongs to the G-protein coupled receptors superfamily. They are activated by extracellular nucleotides and modulate variety of physiological functions.
A new member of this family was recently identified, the P2Y13 receptor.1,2 The P2Y13 receptor has significant similarity to the P2Y12 receptor (about 45% sequence identity) and together they form a distinct group structurally differ from other members of this family. P2Y13 receptor, like the P2Y12 receptor, is a high affinity receptor for the ADP nucleotide, coupled to the Gai class of G-proteins.1,2 The P2Y13 receptor is highly expressed at brain and spleen tissues as well as in the immune system. Lower expression was demonstrated in the testis, lung liver and other peripheral organs.1-3
Recently it has been shown that ADP activates a negative feedback pathway for ATP release from human red blood cells via the P2Y13 receptor.4
P2Y13 receptor was also implicated in inhibition of N-type Ca2+ channels in neurons, exerting pre and/or post-synaptic modulatory action.5