- 貨號 Cat. No.
- APR-009
- 規格 Size
- 50 μl 0.2ml
Description
Anti-P2Y1
Epitope: |
Peptide (C)RALI YKDLD NSPLR RKS, corresponding to residues 242-258 of rat or human P2Y1. (Accession
P49651, P47900). |
Putative epitope location: |
3rd intracellular loop (i3) between TM5 and TM6 domains.
|
Homology: |
Rat, human, bovine - identical; turkey, chicken (16/17 residues identical); mouse (15/17 residues identical).
|
Reactivity Confirmed: |
Rat, human. |
Applications:
 |
Western blotting of rat brain membranes (1,3) or human platelets lysate (2,4).
1, 2. Anti-P2Y1 antibody (1:200).
3, 4. Anti-P2Y1 antibody, preincubated with the control peptide antigen
. |
 |
Immunohistochemical staining of Fasciculi in rat thalamus using Anti-P2Y1 antibody (#APR-009). Specific staining is black, couterstain is cresyl violet. |
1. Wang, L. et al. (2002) J. Cardiovas. Pharmacol. 40, 841. |
2. Queiroz, G. et al. (2003) J. Pharmacol. Exp. Ther. 307, 809. |
3. Ralevic, V. and Burnstock, G. (1998) Pharmacol. Rev. 50, 413. |
4. Abbracchio, M.P. et al. (2003) Trends. Pharmacol. Sci. 24, 52. |
5. Jin, J. et al. (1998) J. Biol. Chem. 273, 2030 |
The P2Y receptors belong to the G-protein coupled receptors superfamily. P2Y receptors mediate the actions of the extracellular nucleotides (ATP, ADP, UTP
and UDP) and regulate several physiologic responses, among them, cardiac function, platelet aggregation and SMC proliferation.1
The mammalian P2Y family currently includes eight functional receptors; P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and the UDP-glucose receptor, now renamed P2Y14.2-4
P2Y1 receptor is abundantly expressed in a number of tissues. In platelets, P2Y1 receptor is co-expressed with P2Y12 receptor, responsible for the initial shape change, aggregation, and rise in intracellular Ca2+ upon activation in response to ADP.5
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