Anti-P2X7
- 貨號 Cat. No.
- APR-004
- 規格 Size
- 50 μl 0.2ml
Description
Anti-P2X7
| Product#: | APR-004 |
| Sizes: |
| 50 µl |
| 0.2 ml |
| Host: |
| Rabbit. |
| Epitope: |
| Peptide (C)KIRK EFPKT QGQYS GFKYP Y, corresponding to amino acid residues 576-595 of rat P2X7 (Accession Q64663). |
 |
| Putative epitope location: |
| Intracellular, C-terminus. |
| Homology: |
Mouse - 18/20 amino acid residues identical; human - 16/20 amino acid residues identical. |
| Reactivity Confirmed: |
Rat, mouse. |
Applications:
| Western Blotting: |
 | Western blot analysis of rat hippocampus lysate: 1. Anti-P2X7 antibody (#APR-004) (1:200). 2. Anti-P2X7 antibody preincubated with the control peptide antigen. |
| Immunohistochemistry: |
| Expression of P2X7 in rat pancreas. |
 | |
|
| References: |
| 1. Ding, Y. et al. (2000) J. Auton. Nerv. Syst. 81, 289. |
| 2. Kim, M. et al. (2001) EMBO J. 20, 6347. |
| 3. Chizh, B.A. and Illes, P. (2001) Pharmacol. Rev. 53, 553. |
The P2X7 receptor is a member of the ionotropic P2X receptor family that is activated by ATP.
To date, this family is composed of seven receptor subtypes, named P2X1-P2X7, all of which have been cloned.
The various P2X receptors show distinct expression patterns. P2X1-6 receptors have been found in the central and peripheral nervous system, while the P2X7 receptor is found in cells of the immune system, particularly in antigen-presenting cells, and microglia.
The P2X7 receptor mediates the release of proinflamatory cytokines and stimulation of transcription factors and may also play an important role in apoptosis.1-3
Alomone Labs offers a highly specific antibody directed against an intracellular epitope of the rat P2X7 receptor channel. The Anti-P2X7 antibody (#APR-004) can be used in Western blot analysis and immunohistochemical applications and recognizes P2X7 from rat, mouse, and human samples.