Anti-P2X6 receptor

Anti-P2X6 receptor

Product#:

APR-013

Sizes:

50 ml

0.2 ml

The P2X receptors belong to the ligand-gated ion channel family and are activated by extracellular ATP.  

P2X receptors are involved in synaptic communication and in diseases of the nervous system.  

The P2X receptors family consist of at least seven isoforms: P2X1-P2X7.^1,2,3  

All P2X subunits can assemble to form homomeric or heteromeric functional channels with the exception  

of P2X6, which only seems to function as part of a heteromeric complex.^4-9  

The P2x6 receptor assembles to a heteromultimer with two other P2X subunits, P2X2 and P2X4.  

The P2X6 receptor is extensively expressed throughout the central nervous system.⁷

Host:

Rabbit.

Epitope:

Peptide (C)RTKYEEARAPKATTNSA, corresponding to residues 363-379 of rat P2X6.   (accession number P51579).

Putative epitope location:

Cytoplasmic.

Homology:

Mouse, Human (15/17 and 14/17 residues identical, respectively)

Reactivity Confirmed:

Rat.

Applications:

Western Blotting:

Rat brain membranes (1:200).

Western blotting of rat brain membranes:  1. Anti- P2X6 antibody (1:200).    2. Anti- P2X6 antibody, preincubated with the control peptide antigen.

Control antigen included in price

References:

1.	Prasad, M.et al. (2001) J. Physiol. 573, 667.
2.	Florenzano, F. et al. (2002) Neuroscience. 115, 425.
3.	Ashcroft, F.M. et al. (2000) J Ion Channels and Disease Ed 1.
4.	Khakh, B.S. et al. (2001) Pharmacol Rev. 53, 107.
5.	Ding, Y. et al. (2000) J. Auton. Nerv. Syst. 81, 289.
6.	Le, K.T. et al. (1998) J. Neurosci. 18, 7152.
7.	Robertson, S.J. et al. (2001) Curr. Opin. Neurol. 11, 378.
8.	Dunn, P.M. et al. (2001) Prog. Neurobiol. 65, 107.
9.	Kim, M. et al. (2001) EMBO J. 20, 6347