Anti-Nav1.8
- 貨號 Cat. No.
- ASC-016
- 規格 Size
- 50 μl 0.2ml
Description
Anti-Nav1.8
A Polyclonal Antibody to Nav1.8 Voltage-Gated Na+ Channels
| Product#: | ASC-016 |
| Sizes: |
| 50 ml |
| 0.2 ml |
a subunits have been cloned and named Nav1.1-1.9. 2-3 The Nav channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive and TTX-resistant channels.4-5 The expression of the a subunit isoforms is developmentally and tissue specific.
| Epitope: |
Peptide (C)EDEVAAKEGNSPGPQ corresponding to amino acid residues 1943-1956 of rat Nav1.8 (Accession Q63554). |
 |
| Putative epitope location: |
C-Terminus, Intracellular. |
| Homology: |
Mouse- 14/15 amino acid residues identical, human-7/15 amino acid residues identical. |
| Reactivity Confirmed: |
| Rat. |
Applications:
| Western Blotting: |
Rat DRG lysates (1:200). |
 | Western blotting of rat DRG lysates:
|
| Immunohistochemistry: |
| Expression of Nav1.8 in rat dorsal root ganglion |
 |
Immunohistochemical staining of NaV1.8 in adult rat dorsal root ganglion (DRG) using Anti-NaV1.8 antibody (#ASC-016). NaV1.8 Staining (red) was cytoplasmic and the intensity varied among DRG cells. There was a partial overlap in the distribution of NaV1.8 and neurofilament 200 (green). |
| References: |
| 1. Wu, L. et al. (2002) NeuroReport 13, 2547. |
| 2. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27. |
| 3. Lai, J. et al. (2003) Curr.Opin. Neurobiol. 13, 291. |
| 4. Fang, X. et al. (2002) J. Neurosci. 22, 7425. |
| 5. Fjell, J. et al. (2000) NeuroReport 11, 199. |
| 6. Renganathan, M. et al. (2003) Brain Res. 959, 235. |
Voltage-gated Na+ channels (Nav) are essential for the generation of action potentials and for cell excitability.1 Nav channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine Nav
Two TTX-resistant Nav channels are expressed in dorsal root ganglion (DRG) neurons, Nav1.8 and Nav1.9. The Nav1.8 channel (also called SNS, SCN10A and PN3) is mainly expressed in small-diameter DRG neurons.4-6 TTX-resistant channels have been suggested to play an important role in nociceptive transmission.
Recently, involvement of Nav1.8 in multiple sclerosis (MS) was suggested due to up-regulation of both, mRNA and protein, in Purkinje cells of MS patients and also in animal models.6
We are pleased to offer Anti-Nav1.8 antibody (#ASC-016) to our growing line of Voltage-Gated Na+ Channel Antibodies.