Anti-Kv7.3 (KCNQ3)
- 貨號 Cat. No.
- APC-051
- 規格 Size
- 50 μl 0.2ml
Description
Anti-Kv7.3 (KCNQ3)
| Product#: | APC-051 |
| Sizes: |
| 50 ml |
| 0.2 ml |
The KCNQ family of voltage-gated K+ channels includes 5 known members: KCNQ1 to KCNQ5.
Structurally, the KCNQ family belongs to the six transmembrane domain category of K+ channels.
KCNQ family members can form either homomultimeric or heteromultimeric channels with different
functional consequences. For example KCNQ2 and KCNQ3 heteromultimers give rise to a much
larger channel current than when either protein is expressed alone, probably due to enhanced
plasma membrane expression of the combined channel. Indeed, KCNQ2/KCNQ3 heteromultimers are
believed to be the molecular correlates of the so-called M current. This current is a K+ neuronal current
that is strongly inhibited by the activation of the M1 subtype of the muscarinic acetylcholine receptor.
Mutations in either KCNQ2 or KCNQ3 are associated with a form of epilepsy known as benign familial
neonatal convulsions (BNFC).
| Host: |
| Rabbit. |
| Epitope: |
| Peptide AEGEKKEDNRYSDLKTIIC, corresponding to amino acid residues 668-686 of rat Kv7.3 (accession number O88944). |
| Putative epitope location: |
| Intracellular, C-terminal part. |
 |
| Homology: |
Mouse - identical; human - 18/19 residues identical. Specificity: The antibody is specific for KCNQ3, |
| Reactivity Confirmed: |
| Rat. |
Applications:
| Western Blotting: |
| Rat brain membranes (1:200). |
 | Western blotting of rat brain membranes: 1. Anti-Kv7.3 (1:200). 2. Anti-Kv7.3, preincubated with the control peptide antigen. |
| Immunohistochemistry: |
| Rat brain sections. |
 |
| KCNQ3 (green) in rat cerebellum was stained by Anti-Kv7.3 antibody (#APC-051). KCNQ3 was localized to the Purkinje cell layer (arrows). Purkinje cells (triangles) were localized using mouse anti- neurofilament 200 (red). |
Control antigen included in price
| References: |
1. | Kullmann, D.M. (2002) J. Mol. Brain 125, 1117. |
2. | Robbins, J. (2001) Pharmacol. Ther. 90, 1. |
3. | Wang, H.S. et al. (1998) Science 282, 1890. |