Anti-Kv7.2 (KCNQ2)

Anti-Kv7.2 (KCNQ2)

Product#:

APC-050

Sizes:

50 ml

0.2 ml

The KCNQ family of voltage-gated K⁺ channels includes 5 known members: KCNQ1 to KCNQ5.  

Structurally, the KCNQ family belongs to the six transmembrane domain category of K⁺ channels.  

KCNQ family members can form either homomultimeric or heteromultimeric channels with different  

functional consequences. For example KCNQ2 and KCNQ3 heteromultimers give rise to a much  

larger channel current than when either protein is expressed alone, probably due to enhanced  

plasma membrane expression of the combined channel. Indeed, KCNQ2/KCNQ3 heteromultimers are  

believed to be the molecular correlates of the so-called M current. This current is a K⁺ neuronal current  

that is strongly inhibited by the activation of the M₁ subtype of the muscarinic acetylcholine receptor.  

Mutations in either KCNQ2 or KCNQ3 are associated with a form of epilepsy known as benign familial  

neonatal convulsions (BNFC).

Host:

Rabbit.

Epitope:

Peptide (C)RGPTITDKDRTKGPAE, corresponding to amino acid residues 578-593 of rat KCNQ2 (Accession number O88943).

Putative epitope location:

Intracellular, C-terminal domain.

Homology:

Mouse ?identical; human- 15/16 residues identical. Specificity:   The antibody is specific for KCNQ2; it does not cross react with KCNQ3 or other QKT proteins.  There are at least 9 recognized splice variants of rat KCNQ2.  This antibody recognizes all except splice variants B and C.

Reactivity Confirmed:

Rat.

Applications:

Western Blotting:

Kv7.2 transfected HEK-293 cells (1:200).

Western blotting of Kv7.2 transfected HEK-293 cells:   1. Anti-Kv7.2 antibody (1:200).    2. Anti-Kv7.2, preincubated with the control peptide antigen.

Control antigen included in price

References:

1.	Kullmann, D.M. (2002) J. Mol. Brain 125, 1117.
2.	Robbins, J. (2001) Pharmacol. Ther. 90, 1.
3.	Wang, H.S. et al. (1998) Science 282, 1890.