Anti-Kv7.1 (KCNQ1)
- 貨號 Cat. No.
- APC-022
- 規格 Size
- 50 μl 0.2ml
Description
Anti-Kv7.1 (KCNQ1)
| Product#: | APC-022 |
| Sizes: |
| 50 ml |
| 0.2 ml |
Kv7.1 (KCNQ1) is part of a voltage-gated K+ family that includes 5 other members (KCNQ1-5).
The channel has been intensively studied since it was found that together with MinK (Isk) it
underlay the cardiac Iks current that controls the duration of the action potential of the human heart.
Indeed mutations on either Kv7.1 or MinK can be responsible for long QT syndrome, a cardiac disorder
that causes arrhythmias and sudden death.
Although Kv7.1 expression and function has been mainly investigated in relation with cardiac function
the channel is widely distributed in epithelial tissues. There it has been implicated in physiological
functions such as: regulation of acid secretion in the stomach and Cl- secretion into the colon.
We now offer an anti-Kv7.1 antibody (#APC-022) raised against a C-terminal epitope of the human protein.
| Host: |
| Rabbit. |
| Epitope: |
Peptide (C)TYEQLTVPRRGPDEGS, corresponding to amino acid residues 661-676 of human Kv7.1 (Accession number P51787). |
 |
| Putative epitope location: |
| Intracellular, C-terminal part. |
| Homology: |
Rat and mouse- 14/16 residues identical. |
| Reactivity Confirmed: |
| Rat. |
Applications:
| Western Blotting: |
| Rat heart membranes (1:200). |
 | Western blotting of rat heart membranes: 1. Anti-Kv7.1 (1:200). 2. Anti-Kv7.1, preincubated with the control peptide antigen |
Control antigen included in price
| References: |
1. | Wang, Q. et al. (1996) Nat. Genet. 12, 17. |
2. | Grahammer, F. et al. (2001) Gastroenterology 120, 1363. |
3. | Mall, M. et al. (1998) Am. J. Physiol. 275, G1274. |