Anti-Kv1.3
- 貨號 Cat. No.
- APC-002
- 規格 Size
- 50 μl 0.2ml
Description
Anti-Kv1.3
| Product#: | APC-002 |
| Sizes: |
| 50 µl |
| 0.2 ml |
| Host: |
| Rabbit |
| Epitope: |
GST fusion protein with sequence TLSKS EYMVI EEGGM NHSAF PQTPF KTGNS TATCT TNNNP NSCVN IKKIF TDV, corresponding to residues 523-575 of human Kv1.3 (Accession P22001). |
 |
| Putative epitope location: |
| Intracellular, C-terminus. |
| Homology: |
rat, rabbit, mouse - identical. |
Applications:
| Western Blotting: |
 | Western blotting of rat brain membranes: 1. Anti-Kv1.3 antibody (#APC-002) (1:200) 2. Anti-Kv1.3 antibody, preincubated with the control antigen. |
| Immunohistochemistry: |
Rat brain sections |
| References: |
| 1. Chandy, K.G.et al. (2001) Toxicon 39, 1269. |
| 2. Koo, G.C. et al. (1997) J Immunol. 158, 5120. |
| 3. Grissmer, S. et al. (1994) Mol. Pharmacol. 45, 1227. |
| 4. Garcia-Calvo, M. et al. (1993) J. Biol. Chem. 268, 18866. |
| 5. Garcia, M. L. et al. (1994) Biochemistry 33, 6834. |
| 6. Koschak, A. et al. (1998) J. Biol. Chem. 273, 2639. |
| 7. Kalman, K. et al. (1998) J. Biol. Chem. 273, 32697. |
Kv1.3 belongs to the Shaker family of voltage-dependent K+ channels.
The channel is widely expressed in the brain, lung and osteoclasts and in several cell
populations of hematopoietic origin. It is in these cells (particularly T lymphocytes) that
Kv1.3 function has centered a lot of attention. It was found that Kv1.3 is the main channel
responsible for maintaining the resting potential in quiescent cells and regulating the
Ca2+ signaling that is indispensable for normal T lymphocyte activation.1,2
Based on the central role of Kv1.3 in regulating the initiation of an immune response,
the channel has been recognized as a potential target for immunosuppressant drugs.1
The channel is widely expressed in the brain, lung and osteoclasts and in several cell
populations of hematopoietic origin. It is in these cells (particularly T lymphocytes) that
Kv1.3 function has centered a lot of attention. It was found that Kv1.3 is the main channel
responsible for maintaining the resting potential in quiescent cells and regulating the
Ca2+ signaling that is indispensable for normal T lymphocyte activation.1,2
Based on the central role of Kv1.3 in regulating the initiation of an immune response,
the channel has been recognized as a potential target for immunosuppressant drugs.1
KV1.3 channels are potently inhibited by several venomous peptide toxins among them
Charybdotoxin (#RTC-325, 2.6nM), Noxiustoxin (#RTN-340, 1nM), Kaliotoxin (#RTK-370, 0.65nM),
Margatoxin (#RTM-325, 0.05nM), Agitoxin-1 (#RTA-150, 1.7nM), Agitoxin-2 (#RTA-420, 0.004nM),
Hongotoxin-1 (#RTH-400, 0.09nM) and Stichodactyla toxin (#S-400, 0.01nM).3-7
Charybdotoxin (#RTC-325, 2.6nM), Noxiustoxin (#RTN-340, 1nM), Kaliotoxin (#RTK-370, 0.65nM),
Margatoxin (#RTM-325, 0.05nM), Agitoxin-1 (#RTA-150, 1.7nM), Agitoxin-2 (#RTA-420, 0.004nM),
Hongotoxin-1 (#RTH-400, 0.09nM) and Stichodactyla toxin (#S-400, 0.01nM).3-7