Anti-Kisspeptins Receptor (extracellular)
- 貨號 Cat. No.
- AKR-001
- 規格 Size
- 50 μl 0.2ml
Description
Anti-Kisspeptins Receptor (extracellular)
| Product#: | AKR-001 |
| Sizes: |
| 50 µl |
| 0.2 ml |
| Host: |
| Rabbit. |
| Epitope: |
Peptide (C)GSWHPRSYAAYALK corresponding to amino acid residues 292-305 of human KISS1R (Accession Q969F8). |
 |
| Putative epitope location: |
3rd extracellular loop. |
| Homology: |
Rat-13/14 amino acid residues identical, Mouse-12/14 amino acid residues identical. |
| Reactivity Confirmed: |
Human, rat. |
Applications:
| Western Blotting: |
 | Western blot analysis of jurkat (lanes 1 and 4), HL-60 (lanes 2 and 5), MCF-7 (lanes 3 and 6) and rat brain (lanes 7 and 8) lysates: 1,2,3,7. Anti- KISS1R (extracellular) antibody (#AKR-001), (1:500). 4,5,6,8. Anti-KISS1R (extracellular) antibody, preincubated with the control peptide antigen. |
| Immunohistochemistry: |
| Expression of KISS1R in rat pancreas |
 |
Immunohistochemical staining of paraffin embedded section of rat pancreas using Anti-KISS1R (extracellular) antibody (#AKR-001) (1:100). KISS1R staining (brown) appears in Isles of Langerhans (IL). Counterstain is Hematoxilin Expression of KISS1R in rat cerebellum |
 |
Immunohistochemical staining of KISS1R in rat cerebellum frozen section using Anti-KISS1R (extracellular) antibody (#AKR-001) (1:100).
|
The Kisspeptins receptor (KISS1R, also named GPCR54) is a member of the G-protein coupled receptor superfamily. The KISS1R natural ligands are peptides called kisspeptins which are encoded by the Kiss1 gene. The Kiss1 gene was originally discovered by Hersheyî–¸ scientists who named it after their famous chocolate, the î˜iss? The kisspeptins, acting through the KISS1R, were found to be potent inhibitors of metastasis in a variety of cancer cell types including thyroid and pancreatic cancer cells. KISS1R and kisspeptins are involved in the direct regulation of the reproductive neuroendocrine axis.
KISS1R is widely distributed throughout the brain, where it is most highly expressed inthe hypothalamic and amygdaloid nuclei. High expression was also found within the pancreas and placenta. Lower-level expression was found in a variety of other peripheral tissues including peripheral blood leukocytes, kidney, lung, testes, spleen, thymus, adrenal glands and lymph nodes. 1-3
Alomone Labs is pleased to offer a highly specific antibody directed against an extracellular epitope of the human Kisspeptins receptor (KISS1R). The Anti-KISS1R (extracellular) antibody (#AKR-001) can be used for Western blot analysis. It has been designed to recognize KISS1R from human, rat and mouse samples.