Anti-Kir2.2

Anti-K_ir2.2

Product#:

APC-042

Sizes:

50 ml

0.2 ml

K_ir2.2 is a member of the inward rectifying K⁺ channel family.  

The K_ir2 subfamily comprises 4 known members: K_ir2.1, K_ir2.2, K_ir2.3 and K_ir2.4.  

The K_ir2 subfamily members are strong inward rectifiers and are believed to be  

involved in maintaining the resting membrane potential and buffering of extracellular K⁺.  

The K_ir2.2 subunit is expressed in the CNS, kidney and heart where it was found to  

form heteromeric channels with K_ir2.1.

Host:

Rabbit.

Epitope:

Peptide (C)EVATDRDGRSPQPEHDFDR,  corresponding to amino acid residues 391-409 of rat Kir2.2 (Accession P52188).

Putative epitope location:

Intracellular, C-terminal part.

Homology:

Mouse identical or 16/19 residues identical; human 13/19 residues identical.

Reactivity Confirmed:

Rat.

Applications:

Western Blotting:

Rat brain membranes (1:200).

Western blotting of rat kidney (1,3) and brain (2,4) membranes:  1,2. Anti-Kir2.2 (1:200).    3,4. Anti-Kir2.2, preincubated with the control peptide antigen.

References:

1. Nichols, C.G. and Lopatin, A.N. (1997) Annu Rev Physiol. 59, 171.

2. Preisig-Muller, R.et al. (2002) PNAS USA 99, 7774