ANTI HUMAN TR ALPHA

Thyroid hormone receptor alpha (TRa, THRA; NR1A1) is a member of nuclear hormone receptors. The ligands for TRa are the thyroid hormones, which exist in two forms: T4 (3,5,3',5'-tetraiodo-L-thyronine) and T3 (3,5,3'- tri-iodo-L-thyronine). TRa plays critical roles in the differentiation, growth, metabolism and physiology of a wide variety of tissues. The major partners of TRs are the RXRs, which strongly enhance their ability to bind to specific DNA sequences and contribute to the specificity of action of TR.