ANTI HUMAN PXR-2

Pregnane-activated receptor (PXR,SXR, PAR, PAR1, PAR2, NR1I2) is a member of nuclear receptor subfamily , which each orthologues historically given different names as pregnane-activated receptor in mice and steroid- and xenobiotic-sensing nuclear receptor in human, PXR binds to rifampicin (an antibiotics) is the most efficient activator in human. Various studies revealed PXR regulates CYP3A gene expression as well as other xenobiotic metabolisms, such as oxidation, conjugation and transport. Many chemicals are known to bind for PXR as activators, eg. the HIV protease inhibitor ritonavir, the anticancer drug paclitaxel, the endocrine disruptor bisphenol A. Expression of PXR founds in the liver, small intestine and colon in the human, rabbit and mouse where CYP3A genes are expressed or induced.