ANTI HUMAN PPAR GAMMA COMMON

Peroxisome proliferator-activated receptor gamma (PPARg; NR1C3) is a member of orphan nuclear receptor. Oxidized metabolites of linoleic acid, 9- hydroxyctadienoic acid (9-HODE) and 13-HODE are activators and ligands of PPARg. PPARg is expressed in white adipose tissue, intestinal mucosa, colon, spleen, monocytes, macrophages, retina, cartilage, osteoclast and skeletal muscle. PPARg plays important roles in lipid and glucose metabolism, and have been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease. Three members were called PPARa, b, g. Three N-terminal isoforms, called g1, g2 and g3, are known to arise by alternative splicing and promoter usage from the PPARg gene. RXR is an obligate partner for PPAR.