ANTI HUMAN PPAR ALPHA

Peroxisome proliferator-activated receptor alpha (PPARa; NR1C1) is a member of orphan nuclear receptor. PPARa exhibit the highest affinity with unsaturated fatty acids, linolenic and linolenic acids. PPARa is expressed in brown fat, liver, kidney, heart, mucosa of the stomach and duodenum, retina, adrenal gland, skeletal muscle, pancreatic islets and smooth muscle cells. PPARa plays important roles in lipid and glucose metabolism, and have been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease. Three members were called PPARa, b, g. RXR is an obligate partner for PPAR.