ANTI HUMAN MR

Mineralcorticoid receptor (MR; NR3C2) is a member of steroid receptor (AR, ER, GR, PR). Aldosterone binds to MR with a high affinity. MR is expressed in kidney, gut, brain, pituitary, hypothalamus and heart. MR plays a critical role in regulating electrolyte and fluid balance in the kidney, as well as having specific roles in the central nervous system. The protein is expressed as a 107 kDa nuclear form. MR and GR can cooperatively form heterodimers.