ANTI HUMAN FXR

Farnesoid X-activated receptor (FXR, HRR-1, BAR, RIP14; NR1H4) is a member of orphan nuclear receptor. FXR is expressed in liver, intestinal villi, renal tubes and adrenal cortex. FXR is a global regulator of bile acid metabolism. Two genes, cholesterol 7a-hydroxylase (CYP7A1) and IBABP (ileal bile acid binding protein), which are implicated in bile acid biosynthesis and recycling, respectively, are target genes of FXR. FXR was shown to be transcriptionally activated by falnesol metabolites such as farnesol itself, juvenile hormone III. FXR binds to DNA only as a heterodimer with RXR.