ANTI HUMAN ER ALPHA

Estrogen receptor alpha (ERa, ER; NR3A1) is a member of steroid receptor (AR, GR, MR, PR). The natural ligand for ER is the classical estrogenic compound 17b-estradiol. ERa is expressed in a wide variety of tissues. Expression was found at variable levels in bones, in uterus, bladder, ovary, prostate, testis, epididymys, kidney, breast, heart, vessel wall, pituitary and hypothalamus. ER has a variety of central physiological roles, including those involved in maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. ERa has been shown to form homodimers as well as heterodimers with ERb. Both ERa and ERb can give rise to numerous isoforms.