Anti-human Cav1.2
- 貨號 Cat. No.
- ACC-022
- 規格 Size
- 50 μl 0.2ml
Description
Anti-human Cav1.2 (human a1C)
A Polyclonal Antibody to hCav1.2 Ca2+ Channels
| Product#: | ACC-022 |
| Sizes: |
| 50 ml |
| 0.2 ml |
| Host: |
| Rabbit. |
| Epitope: |
Peptide VNENTRMYIPEENHQ(C) corresponding to residues 2-15 of human Cav1.2 (exon 1B) (Accession Q13936). |
 |
| Putative epitope location: |
Intracellular, N-Terminus. |
| Homology: |
Mouse, rat ?14/15 Specificity: The antibody recognizes mouse Cav1.2, splice variants P22002-4 and P22002-5 of rat Cav1.2 and splice variant P15381-4 of rabbit Cav1.2. residues identical. |
| Reactivity Confirmed: |
| Rat. |
Applications:
| Western Blotting: |
 | Western blotting of rat heart membranes: 1. Anti-human-Cav1.2 antibody (1:200). 2. Anti-human-Cav1.2 antibody, preincubated with the control peptide. |
Control antigen included in price
| References: |
1. | Catterall, W.A. et al. (2003) Pharmacol. Rev. 55, 579. |
2. | http://www.iuphar-db.org/iuphar-ic/calcium.html |
All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptor. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous and CaV1.3 channels are found in heart, brain and pancreas. Several peptidyl toxins are described that are specific L-type channels blockers, but so far no selective blocker for one of the CaV1 isoforms have been described. These include the Mamba toxins Calcicludine (#C-650), Calciseptine (#C-500) and FS-2 (#F-700).
We are pleased to introduce Anti-human CaV1.2 antibody (#ACC-022) to our growing line of voltage-gated Ca2+ channel antibodies.