ANTI-HUMAN BCL6

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STARTdependent IL-4 responses of B cells. This protein can interact with a variety of POZcontaining proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL..[NCBI Entrez Gene Summary]