ANTI HUMAN AR

Androgen receptor (AR; NR3C4) is a member of steroid receptor (ER, GR, MR, PR). 5a-dihydroteststerone can bind to the AR as a ligand. AR is expressed in most tissues. AR is associated with at least three types of diseases: X-linked androgen insensivity, spinal/bulbar musclar atrophy and cancer. In presence of its ligand, AR binds as a homodimer to sequence called ARE (androgen response element). AR has been shown to be able to form heterodimers with GR. Two isoforms of AR were identified in human genital skin fibroblasts. The large isoform of 110 kDa (called AR-B) corresponds to the bona fide receptor, whereas the small one of 87 kDa (AR-A) initiate on an internal initiation codon.