- 貨號 Cat. No.
- AGR-003
- 規格 Size
- 50 μl 0.2ml
Description
Anti-Glycine Receptor a3
(GlyRa3)
Epitope: |
Peptide, (C)KNKTEAFALEKFYR corresponding to residues 355-368 of rat GlyRa3 (accession number P24524). |
Putative epitope location: |
Cytoplasmic. |
Homology: |
Mouse, Human-identical. |
Reactivity Confirmed: |
Rat. |
Applications:
Western Blotting: |
Rat brain membranes (1:200). |
 |
Western blotting of rat brain membranes:
1. Anti-GlyRa3 antibody (1:200).
2. Anti- GlyRa3 antibody, preincubated with the control peptide antigen. |
1. Becker, C.M. (1995) The Neuroscientist 1, 130.
|
2. Gisselmann, G. et al. (2002) Eur. J. Neurosci. 16, 69.
|
3. Nikolic, Z. et al. (1998) J. Biol. Chem. 273, 19708.
|
4. Breitinger, H.G. et al. (2002) J.Neurochem. 83, 30. |
Glycine is a major neurotransmitter in the mammalian central nervous system.1
The glycine receptor is a ligand gated Cl- channel, mediating synaptic inhibition
in the spinal cord, retina and regions of the brain.2
The glycine receptor is a pentamer consisting of a and b subunits.
To date there are four known a-subunit isoforms (a1- a4) encoded by
different genes.2-4
In humans, two alternative splice variants of the glycine receptor a3 have been described:
a3L, and a3K where the a3L splice variant bears an additional segment of 15
amino acids within the long cytoplasmic TM3-4 loop.
These variants differ in their desensitization kinetics.3
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